Correlated evolution of interacting proteins: looking behind the mirrortree.

ABSTRACT: It has been observed that the evolutionary distances of interacting proteins often display a higher level of similarity than those of noninteracting proteins. This finding indicates that interacting proteins are subject to common evolutionary constraints and constitutes the basis of a method to predict protein interactions known as mirrortree. It has been difficult, however, to identify the direct cause of the observed similarities between evolutionary trees. One possible explanation is the existence of compensatory mutations between partners' binding sites to maintain proper binding. This explanation, though, has been recently challenged, and it has been suggested that the signal of correlated evolution uncovered by the mirrortree method is unrelated to any correlated evolution between bi

SUBMITTER: Kann MG 

PROVIDER: S-EPMC2678019 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature