Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development.

ABSTRACT:

Background

Down syndrome is a chromosomal disorder caused by the presence of three copies of chromosome 21. The mechanisms by which this aneuploidy produces the complex and variable phenotype observed in people with Down syndrome are still under discussion. Recent studies have demonstrated an increased transcript level of the three-copy genes with some dosage compensation or amplification for a subset of them. The impact of this gene dosage effect on the whole transcriptome is still debated and longitudinal studies assessing the variability among samples, tissues and developmental stages are needed.

Results

We thus designed a large scale gene expression study in mice (the Ts1Cje Down syndrome mouse model) in which we could measure the effects of trisomy 21 on a large number

SUBMITTER: Laffaire J 

PROVIDER: S-EPMC2678156 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature