Flexible neural mechanisms of cognitive control within human prefrontal cortex.

ABSTRACT: A major challenge in research on executive control is to reveal its functional decomposition into underlying neural mechanisms. A typical assumption is that this decomposition occurs solely through anatomically based dissociations. Here we tested an alternative hypothesis that different cognitive control processes may be implemented within the same brain regions, with fractionation and dissociation occurring on the basis of temporal dynamics. Regions within lateral prefrontal cortex (PFC) were examined that, in a prior study, exhibited contrasting temporal dynamics between older and younger adults during performance of the AX-CPT cognitive control task. The temporal dynamics in younger adults fit a proactive control pattern (primarily cue-based activation), whereas in older adults a reacti

SUBMITTER: Braver TS 

PROVIDER: S-EPMC2678630 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature