Total synthesis and absolute configuration of the bisanthraquinone antibiotic BE-43472B.

ABSTRACT: An-T-biotic: The first total synthesis of the T-shaped bisanthraquinone natural product BE-43472B was accomplished and its absolute configuration assigned. Key transformations in the pivotal cascade sequence include a Diels-Alder reaction, a hemiketal formation, and a nucleophilic aromatic ipso substitution.

SUBMITTER: Nicolaou KC 

PROVIDER: S-EPMC2678724 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature