Pathway and network-based analysis of genome-wide association studies in multiple sclerosis.

ABSTRACT: Genome-wide association studies (GWAS) testing several hundred thousand SNPs have been performed in multiple sclerosis (MS) and other complex diseases. Typically, the number of markers in which the evidence for association exceeds the genome-wide significance threshold is very small, and markers that do not exceed this threshold are generally neglected. Classical statistical analysis of these datasets in MS revealed genes with known immunological functions. However, many of the markers showing modest association may represent false negatives. We hypothesize that certain combinations of genes flagged by these markers can be identified if they belong to a common biological pathway. Here we conduct a pathway-oriented analysis of two GWAS in MS that takes into account all SNPs with nominal evi

SUBMITTER: Baranzini SE 

PROVIDER: S-EPMC2678928 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature