Time-dependent interactions of the hypotensive effects of sildenafil citrate and sublingual glyceryl trinitrate.

ABSTRACT:

Aim

To investigate the time course of the hypotensive interaction between sildenafil and glyceryl trinitrate (GTN).

Methods

Two double-blind, placebo-controlled, randomized, crossover studies were performed. Subjects were challenged with sublingual GTN 400 microg at different times after oral sildenafil 100 mg. After each GTN challenge frequent measures of blood pressure (BP) were made. In the first study GTN was given 1-48 h after sildenafil/placebo to 33 healthy men. In the second study GTN was given 1-8 h after sildenafil/placebo to 20 men with stable angina.

Results

In healthy men there was a greater mean maximum reduction in BP with sildenafil/GTN than with placebo/GTN only at 1 h. In angina patients, there was a greater mean maximum reduction in BP with sildenaf

SUBMITTER: Oliver JJ 

PROVIDER: S-EPMC2679103 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature