Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart.

ABSTRACT:

Background

The Akt protein kinase is an important mediator of cardiac myocyte growth and survival. To identify factors with novel therapeutic applications in cardiac diseases, we focused on the identification of factors secreted from Akt1-activated cells that have cardioprotective effects through autocrine/paracrine mechanisms.

Methods and results

Using an inducible Akt1 transgenic mouse model, we have found that follistatin-like 1 (Fstl1) protein and transcript expression are increased 4.0- and 2.0-fold, respectively, by Akt activation in the heart (P<0.05). Fstl1 transcript was also upregulated in response to myocardial stresses including transverse aortic constriction, ischemia/reperfusion injury, and myocardial infarction. Adenovirus-mediated overexpression of Fstl1 prot

SUBMITTER: Oshima Y 

PROVIDER: S-EPMC2679251 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature