Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells.

ABSTRACT:

Background

Oxidative stress and excitotoxicity underlie the developmental neurotoxicity of numerous chemicals.

Objectives

We compared the effects of organophosphates (chlorpyrifos and diazinon), an organo-chlorine (dieldrin), and a metal [divalent nickel (Ni2+)] to determine how these mechanisms contribute to similar or dissimilar neurotoxic outcomes.

Methods

We used PC12 cells as a model of developing neurons and evaluated transcriptional profiles for genes for oxidative stress responses and glutamate receptors.

Results

Chlorpyrifos had a greater effect on oxidative-stress-related genes in differentiating cells compared with the undifferentiated state. Chlorpyrifos and diazinon showed significant concordance in their effects on glutathione-related genes, but t

SUBMITTER: Slotkin TA 

PROVIDER: S-EPMC2679603 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature