Serological evidence of infections and Type 2 diabetes: the MultiEthnic Study of Atherosclerosis.

ABSTRACT:

Aims

Prospective studies have identified chronic inflammation as a risk factor for Type 2 diabetes. However, it is not known whether infection by specific pathogens or having a greater 'pathogen burden' is associated with diabetes. The aim of this study was to examine the cross-sectional relation of seropositivity to five pathogens (Chlamydia pneumoniae, cytomegalovirus, Helicobacter pylori, hepatitis A virus, herpes simplex virus) and prevalent diabetes.

Methods

Baseline data from a random sample of MultiEthnic Study of Atherosclerosis (MESA) participants (n = 1000; age 45-84 years) were used. Diabetes was defined by American Diabetes Association 2003 criteria, and 'pathogen burden' by the number of pathogens (0-5) for which an individual was seropositive. Logistic regressi

SUBMITTER: Lutsey PL 

PROVIDER: S-EPMC2679689 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature