Association of serotonin transporter gene polymorphisms with poststroke depression.

ABSTRACT:

Context

Polymorphisms of the serotonin transporter gene (SERT) have been associated with mental illness. In people with long-term medical conditions, variants of the 5-HTTLPR and STin2 VNTR polymorphisms of SERT have been shown to confer a heightened vulnerability to comorbid depression.

Objective

To determine whether the 5-HTTLPR, STin2 VNTR, and rs25531 polymorphisms of SERT are associated with poststroke depression (PSD) in stroke survivors.

Design

A case-control study in which stroke survivors were screened for depressive symptoms and assigned to either a depressed group or a nondepressed group.

Setting

Outpatient clinic.

Participants

Seventy-five stroke survivors with PSD and 75 nondepressed stroke survivors.

Interventions

Blood or saliva sam

SUBMITTER: Kohen R 

PROVIDER: S-EPMC2679964 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature