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Feedback loops shape cellular signals in space and time.

ABSTRACT: Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems.

SUBMITTER: Brandman O 

PROVIDER: S-EPMC2680159 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Feedback loops shape cellular signals in space and time.

Brandman Onn O   Meyer Tobias T  

Science (New York, N.Y.) 20081001 5900

Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems. ...[more]

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