Genomic complexity of the Y-STR DYS19: inversions, deletions and founder lineages carrying duplications.

ABSTRACT: The Y-STR DYS19 is firmly established in the repertoire of Y-chromosomal markers used in forensic analysis yet is poorly understood at the molecular level, lying in a complex genomic environment and exhibiting null alleles, as well as duplications and occasional triplications in population samples. Here, we analyse three null alleles and 51 duplications and show that DYS19 can also be involved in inversion events, so that even its location within the short arm of the Y chromosome is uncertain. Deletion mapping in the three chromosomes carrying null alleles shows that their deletions are less than approximately 300 kb in size. Haplotypic analysis with binary markers shows that they belong to three different haplogroups and so represent independent events. In contrast, a collection of 51 DYS

SUBMITTER: Balaresque P 

PROVIDER: S-EPMC2680205 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature