Role of the tau gene region chromosome inversion in progressive supranuclear palsy, corticobasal degeneration, and related disorders.

ABSTRACT:

Background

An inverted region on chromosome 17 has been previously linked to many Pick complex diseases. Due to the inversion, an exact causal locus has been difficult to identify, but the microtubule-associated protein tau gene is a likely candidate gene for its involvement in these diseases with tau inclusion.

Objective

To search for variants that confer susceptibility to 4 tauopathies and clinically related disorders.

Design

Genomewide association study.

Setting

University research laboratory.

Participants

A total of 231 samples were genotyped from an unrelated white population of patients with progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), frontotemporal dementia, and frontotemporal dementia with amyotrophy. Unaffected individ

SUBMITTER: Webb A 

PROVIDER: S-EPMC2680206 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature