Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico.

ABSTRACT: Mexico is developing the basis for genomic medicine to improve healthcare of its population. The extensive study of genetic diversity and linkage disequilibrium structure of different populations has made it possible to develop tagging and imputation strategies to comprehensively analyze common genetic variation in association studies of complex diseases. We assessed the benefit of a Mexican haplotype map to improve identification of genes related to common diseases in the Mexican population. We evaluated genetic diversity, linkage disequilibrium patterns, and extent of haplotype sharing using genomewide data from Mexican Mestizos from regions with different histories of admixture and particular population dynamics. Ancestry was evaluated by including 1 Mexican Amerindian group and data fr

SUBMITTER: Silva-Zolezzi I 

PROVIDER: S-EPMC2680428 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature