Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon.

ABSTRACT:

Background

Genetic variation has been shown to play a significant role in determining susceptibility to the salmon louse, Lepeophtheirus salmonis. However, the mechanisms involved in differential response to infection remain poorly understood. Recent findings in Atlantic salmon (Salmo salar) have provided evidence for a potential link between marker variation at the major histocompatibility complex (MHC) and differences in lice abundance among infected siblings, suggesting that MHC genes can modulate susceptibility to the parasite. In this study, we used quantitative trait locus (QTL) analysis to test the effect of genomic regions linked to MHC class I and II on linkage groups (LG) 15 and 6, respectively.

Results

Significant QTL effects were detected on both LG 6 and LG 15 i

SUBMITTER: Gharbi K 

PROVIDER: S-EPMC2680909 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature