Association of the calcium-sensing receptor gene with blood pressure and urinary calcium in African-Americans.

ABSTRACT:

Context

Calcium binding to the Ca-sensing receptor (CASR) expressed in thick ascending limb inhibits the Na,K,2Cl cotransporter, which decreases sodium reabsorption and secondarily decreases Ca reabsorption. CASR gene variants could influence blood pressure (BP) by affecting Na retention.

Objective

The objective of the study was to determine whether variations in CASR associated with BP in African-Americans, an ethnic group at high risk for hypertension.

Design

Population- and family-based association studies of single-nucleotide polymorphisms (SNPs) in CASR with BP measured over the age range 5.6-25 yr (14 biannual visits per subject on average) were carried out. In a cross-sectional study where urinary Ca excretion had been measured, Ca excretion was used as an addi

SUBMITTER: Jung J 

PROVIDER: S-EPMC2681276 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature