Association between serum osteocalcin and markers of metabolic phenotype.

ABSTRACT:

Context

Osteocalcin has been reported to contribute to the regulation of glucose tolerance and insulin secretion and sensitivity in experimental animals.

Objective

Our objective was to examine the association between serum osteocalcin concentration and markers of dysmetabolic phenotype using data from a completed clinical trial in adults age 65 and older [n = 380, mean age 71 yr, body mass index (BMI) 26.9 kg/m(2), 5% with diabetes].

Research design and methods

In cross-sectional analyses (baseline data), we estimated the associations of serum osteocalcin and urine N-telopeptide with markers of metabolic phenotype including fasting plasma glucose (FPG) (primary outcome), fasting insulin, insulin sensitivity estimated by homeostasis model assessment for insulin resista

SUBMITTER: Pittas AG 

PROVIDER: S-EPMC2681283 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature