Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate.

ABSTRACT:

Objectives

We examined the association between candidate single nucleotide polymorphisms (SNPs) and disease activity in RA patients on MTX.

Methods

Our population was drawn from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS), a prospective, observational cohort of RA patients. A total of 556 participants were genotyped using the Affymetrix 100K platform. Two hundred and sixty-two participants were on MTX therapy, including 120 on MTX monotherapy. The primary outcome was the disease activity score in 28 joints (DAS28-CRP). High disease activity was defined as DAS28-CRP >3.2. Low disease activity was defined as DAS28-CRP < or =3.2. We studied three candidate alleles in the ATIC, ITPA and MTHFR genes for association with DAS28-CRP.

Results

SUBMITTER: Lee YC 

PROVIDER: S-EPMC2681284 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature