Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution.

ABSTRACT:

Background

Genome comparisons have made possible the reconstruction of the eutherian ancestral karyotype but also have the potential to provide new insights into the evolutionary inter-relationship of the different eutherian orders within the mammalian phylogenetic tree. Such comparisons can additionally reveal (i) the nature of the DNA sequences present within the evolutionary breakpoint regions and (ii) whether or not the evolutionary breakpoints occur randomly across the genome. Gene synteny analysis (E-painting) not only greatly reduces the complexity of comparative genome sequence analysis but also extends its evolutionary reach.

Results

E-painting was used to compare the genome sequences of six different mammalian species and chicken. A total of 526 evolutionary breakp

SUBMITTER: Kemkemer C 

PROVIDER: S-EPMC2681463 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature