Genome wide signatures of positive selection: the comparison of independent samples and the identification of regions associated to traits.

ABSTRACT:

Background

The goal of genome wide analyses of polymorphisms is to achieve a better understanding of the link between genotype and phenotype. Part of that goal is to understand the selective forces that have operated on a population.

Results

In this study we compared the signals of selection, identified through population divergence in the Bovine HapMap project, to those found in an independent sample of cattle from Australia. Evidence for population differentiation across the genome, as measured by FST, was highly correlated in the two data sets. Nevertheless, 40% of the variance in FST between the two studies was attributed to the differences in breed composition. Seventy six percent of the variance in FST was attributed to differences in SNP composition and density when t

SUBMITTER: Barendse W 

PROVIDER: S-EPMC2681478 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature