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Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species.

ABSTRACT: The essential oil of Helichrysum italicum significantly reduces the multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Combinations of the two most active fractions of the essential oil with each other or with phenylalanine arginine beta-naphthylamide yield synergistic activity. Geraniol, a component of one fraction, significantly increased the efficacy of beta-lactams, quinolones, and chloramphenicol.

SUBMITTER: Lorenzi V 

PROVIDER: S-EPMC2681508 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species.

Lorenzi Vannina V   Muselli Alain A   Bernardini Antoine François AF   Berti Liliane L   Pagès Jean-Marie JM   Amaral Leonard L   Bolla Jean-Michel JM  

Antimicrobial agents and chemotherapy 20090302 5

The essential oil of Helichrysum italicum significantly reduces the multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Combinations of the two most active fractions of the essential oil with each other or with phenylalanine arginine beta-naphthylamide yield synergistic activity. Geraniol, a component of one fraction, significantly increased the efficacy of beta-lactams, quinolones, and chloramphenicol. ...[more]

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