Bile-inducible efflux transporter from Bifidobacterium longum NCC2705, conferring bile resistance.

ABSTRACT: Bifidobacteria are normal inhabitants of the human gut. Some strains of this genus are considered health promoting or probiotic, being included in numerous food products. In order to exert their health benefits, these bacteria must overcome biological barriers, including bile salts, to colonize and survive in specific parts of the intestinal tract. The role of multidrug resistance (MDR) transporters in bile resistance of probiotic bacteria and the effect of bile on probiotic gene expression are not fully understood. In the present study, the effect of subinhibitory concentrations of bile on the expression levels of predicted MDR genes from three different bifidobacterial strains, belonging to Bifidobacterium longum subsp. longum, Bifidobacterium breve, and Bifidobacterium animalis subsp. l

SUBMITTER: Gueimonde M 

PROVIDER: S-EPMC2681658 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature