A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study.

ABSTRACT:

Aims

Recent studies showed that polymorphisms on chromosome 9p21 are associated with coronary heart disease (CHD), but few studies examined the association with heart failure (HF), stroke, or other subclinical atherosclerotic diseases. We tested the association of chromosome 9p21 polymorphisms with non-coronary atherosclerotic diseases.

Methods and results

We studied 4018 African-American and 11 085 white participants from the Atherosclerosis Risk in Communities Study, aged 45-64 at baseline (1987-89). We examined associations of rs10757274 and rs2383206 polymorphisms with incident HF through 2005 and ischaemic stroke through 2004, and with prevalent carotid atherosclerosis and peripheral artery disease (PAD) at baseline. The GG genotype of rs10757274 was associated with inc

SUBMITTER: Yamagishi K 

PROVIDER: S-EPMC2682194 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature