An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders.

ABSTRACT:

Background

Human anxiety disorders are complex diseases with largely unknown etiology. We have taken a cross-species approach to identify genes that regulate anxiety-like behavior with inbred mouse strains that differ in their innate anxiety levels as a model. We previously identified 17 genes with expression levels that correlate with anxiety behavior across the studied strains. In the present study, we tested their 13 known human homologues as candidate genes for human anxiety disorders with a genetic association study.

Methods

We describe an anxiety disorder study sample derived from a Finnish population-based cohort and consisting of 321 patients and 653 carefully matched control subjects, all interviewed to obtain DSM-IV diagnoses. We genotyped altogether 208 single nuc

SUBMITTER: Donner J 

PROVIDER: S-EPMC2682432 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature