Homocysteine levels and risk of hip fracture in postmenopausal women.

ABSTRACT:

Background

Recent studies suggest that high homocysteine levels are associated with an increased risk of fractures. Homocysteine levels are known to be influenced by vitamin B and folate supply or status, and poor renal function can result in higher levels independent of nutritional adequacy.

Objective

The aim of the study was to determine the associations between fasting homocysteine levels and incident hip fractures, and the effects of other factors on hip fracture risk.

Design

We conducted a case-control study in the Women's Health Initiative Observational Study, a study of postmenopausal women (n = 93,676) recruited in the United States. We selected 400 incident cases of hip fracture and 400 controls matched on age, ethnicity, and blood draw date among women not o

SUBMITTER: Leboff MS 

PROVIDER: S-EPMC2682463 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature