Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families.

ABSTRACT:

Context

Epidemiological data support a shared genetic susceptibility to autoimmune thyroid disease (AITD) and type 1 diabetes (T1D). Both diseases frequently occur within the same family and in the same individual. Patients developing both T1D and AITD are considered to have an autoimmune polyglandular syndrome type 3 variant (APS3v).

Objective

The goals of this study were to identify the joint susceptibility loci/genes for T1D and AITD.

Settings

The study was conducted at an academic medical center.

Participants and main outcome measures

We used whole genome and candidate gene approaches in a data set of 88 families multiplex for T1D and AITD (448 individuals).

Results

We identified three loci, on chromosomes 2p, 6p, and Xp, showing linkage when individ

SUBMITTER: Villano MJ 

PROVIDER: S-EPMC2682473 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature