Blunted sleep-related luteinizing hormone rise in healthy premenarcheal pubertal girls with elevated body mass index.

ABSTRACT:

Objective

Our objective was to determine whether excessive adiposity is associated with alteration of the normal hormonal changes of early pubertal girls.

Design and participants

Healthy 6.4- to 9.5-yr-old, prepubertal (PRE, n = 20) and 9.4- to 13.0-yr-old pubertal premenarcheal volunteers (PUB, n = 20) were divided into excessive-weight (EW) or normal-weight (NW) groups according to the 85th percentile body mass index. INTERVENTIONS AND SETTING: Overnight blood sampling; GnRH agonist (GnRHag), low-dose ACTH, oral glucose tolerance tests, and pelvic ultrasonograms were performed in our Clinical Research Center.

Results

EW girls were similar in age and baseline and ACTH- and GnRHag-stimulated androgen levels to stage-matched NW girls. However, the sleep-related LH rise

SUBMITTER: Bordini B 

PROVIDER: S-EPMC2682481 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature