Three distinct condensin complexes control C. elegans chromosome dynamics.

ABSTRACT:

Background

Condensin complexes organize chromosome structure and facilitate chromosome segregation. Higher eukaryotes have two complexes, condensin I and condensin II, each essential for chromosome segregation. The nematode Caenorhabditis elegans was considered an exception, because it has a mitotic condensin II complex but appeared to lack mitotic condensin I. Instead, its condensin I-like complex (here called condensin I(DC)) dampens gene expression along hermaphrodite X chromosomes during dosage compensation.

Results

Here we report the discovery of a third condensin complex, condensin I, in C. elegans. We identify new condensin subunits and show that each complex has a conserved five-subunit composition. Condensin I differs from condensin I(DC) by only a single subunit. Y

SUBMITTER: Csankovszki G 

PROVIDER: S-EPMC2682549 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature