Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes.

ABSTRACT:

Objective

Despite extensive evidence for genetic susceptibility to diabetic nephropathy, the identification of susceptibility genes and their variants has had limited success. To search for genes that contribute to diabetic nephropathy, a genome-wide association scan was implemented on the Genetics of Kidneys in Diabetes collection.

Research design and methods

We genotyped approximately 360,000 single nucleotide polymorphisms (SNPs) in 820 case subjects (284 with proteinuria and 536 with end-stage renal disease) and 885 control subjects with type 1 diabetes. Confirmation of implicated SNPs was sought in 1,304 participants of the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study, a long-term, prospective inve

SUBMITTER: Pezzolesi MG 

PROVIDER: S-EPMC2682673 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature