Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.

ABSTRACT:

Objective

Recent genome-wide association studies have resulted in a dramatic increase in our knowledge of the genetic loci involved in type 2 diabetes. In a complementary approach to these single-marker studies, we attempted to identify biological pathways associated with type 2 diabetes. This approach could allow us to identify additional risk loci.

Research design and methods

We used individual level genotype data generated from the Wellcome Trust Case Control Consortium (WTCCC) type 2 diabetes study, consisting of 393,143 autosomal SNPs, genotyped across 1,924 case subjects and 2,938 control subjects. We sought additional evidence from summary level data available from the Diabetes Genetics Initiative (DGI) and the Finland-United States Investigation of NIDDM Genetics (FU

SUBMITTER: Perry JR 

PROVIDER: S-EPMC2682674 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature