Vitamin K supplementation and progression of coronary artery calcium in older men and women.

ABSTRACT:

Background

Coronary artery calcification (CAC) is an independent predictor of cardiovascular disease. A preventive role for vitamin K in CAC progression has been proposed on the basis of the properties of matrix Gla protein (MGP) as a vitamin K-dependent calcification inhibitor.

Objective

The objective was to determine the effect of phylloquinone (vitamin K1) supplementation on CAC progression in older men and women.

Design

CAC was measured at baseline and after 3 y of follow-up in 388 healthy men and postmenopausal women; 200 received a multivitamin with 500 microg phylloquinone/d (treatment), and 188 received a multivitamin alone (control).

Results

In an intention-to-treat analysis, there was no difference in CAC progression between the phylloquinone group an

SUBMITTER: Shea MK 

PROVIDER: S-EPMC2682995 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature