Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice.

ABSTRACT:

Objective

High-density lipoprotein (HDL) receptor, scavenger receptor class B, type I (SR-BI), mediated cellular uptake of lipoprotein cholesterol controls HDL structure and plasma HDL and biliary cholesterol levels. In SR-BI knockout (KO) mice, an unusually high plasma unesterified-to-total cholesterol ratio (UC:TC) and abnormally large HDL particles apparently contribute to pathology, including female infertility, susceptibility to atherosclerosis and coronary heart disease, and anemia. Here we examined the influence of SR-BI deficiency on platelets.

Methods and results

The high plasma UC:TC ratio in SR-BI KO mice was correlated with platelet abnormalities, including high cholesterol content, abnormal morphologies, high clearance rates, and thrombocytopenia. One day after

SUBMITTER: Dole VS 

PROVIDER: S-EPMC2683374 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature