Analysis of single nucleotide polymorphisms of CRYGA and CRYGB genes in control population of western Indian origin.

ABSTRACT:

Aim

Polymorphisms in gamma-crystallins ( CRYG ) can serve as markers for lens differentiation and eye disorders leading to cataract. Several investigators have reported the presence of sequence variations within crystallin genes, with or without apparent effects on the function of the proteins both in mice and humans. Delineation of these polymorphic sites may explain the differences observed in the susceptibility to cataract observed among various ethnic groups. An easier Restriction Fragment Length Polymorphism (RFLP)-based method has been used to detect the frequency of four single nucleotide polymorphisms (SNPs) in CRYGA / CRYGB genes in control subjects of western Indian origin.

Materials and methods

A total of 137 healthy volunteers from western India were studied. Exa

SUBMITTER: Kapur S 

PROVIDER: S-EPMC2683433 | biostudies-literature | 2009 May-Jun

REPOSITORIES: biostudies-literature