A sequence and structure based method to predict putative substrates, functions and regulatory networks of endo proteases.

ABSTRACT:

Background

Proteases play a central role in cellular homeostasis and are responsible for the spatio-temporal regulation of function. Many putative proteases have been recently identified through genomic approaches, leading to a surge in global profiling attempts to characterize their function. Through such efforts and others it has become evident that many proteases play non-traditional roles. Accordingly, the number and the variety of the substrate repertoire of proteases are expected to be much larger than previously assumed. In line with such global profiling attempts, we present here a method for the prediction of natural substrates of endo proteases (human proteases used as an example) by employing short peptide sequences as specificity determinants.

Methodology/principal f

SUBMITTER: Venkatraman P 

PROVIDER: S-EPMC2683571 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature