Protein electrophile-binding motifs: lysine-rich proteins are preferential targets of quinones.

ABSTRACT: Quinones represent an important class of endogenous compounds such as neurotransmitters and coenzyme Q10, electrophilic xenobiotics, and environmental toxicants that have known reactivity based on their ability to redox cycle and generate oxidative stress, as well as to alkylate target proteins. It is likely that topological, chemical, and physical features combine to determine which proteins become targets for chemical adduction. Chemical-induced post-translational modification of certain critical proteins causes a change in structure/function that contributes to the toxicological response to chemical exposure. In this study, we have identified a number of proteins that are modified by quinone-thioethers after administration of 2-(glutathion-S-yl)HQ. Parallel one-dimensional gel electroph

SUBMITTER: Labenski MT 

PROVIDER: S-EPMC2683689 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature