Influence of quasispecies on virological responses and disease severity in patients with chronic hepatitis C.

ABSTRACT:

Aim

To elucidate the influence of quasispecies on virological response and disease severity in patients with chronic hepatitis C.

Methods

Forty seven patients with hepatitis C [32 with chronic active hepatitis (CAH), 9 with cirrhosis, and 6 with hepatocellular carcinoma (HCC)] were screened for the presence of quasispecies by single stranded conformational polymorphism (SSCP) analysis in the hypervariable region (HVR) and non-structural 5B (NS5B) viral genes of hepatitis C virus. The 41 patients excluding those with HCC were on therapy and followed up for a year with the determination of virological response and disease severity. Virus isolated from twenty three randomly selected patients (11 non-responders and 12 showing a sustained virological response) was sequenced for t

SUBMITTER: Kumar D 

PROVIDER: S-EPMC2683995 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature