Genome-wide detection of hybrid genes with multiple components in human.

ABSTRACT:

Background

Previous studies showed that gene hybrid is one of the principal processes for generating new genes. Although some gene hybrid events have been reported to be inter- or intra-species, there lacks a well-organized method for large scale detection of the events with multiple components. Hence in this study, we focus on building up an efficient method for exploring all candidates of gene hybrid events in human genome and provide useful results for further study.

Findings

We have developed a method designated Triad Comparison Algorithm (TCA) to detect all potential N-hybrid events (i.e., an N-hybrid gene and its N non-overlapping component regions derived from N different genes) in human genome. The results reveal that there are many convoluted N-hybrid events with mu

SUBMITTER: Tzeng YH 

PROVIDER: S-EPMC2684099 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature