Development of a fingerprinting panel using medically relevant polymorphisms.

ABSTRACT:

Background

For population based biorepositories to be of use, rigorous quality control and assurance must be maintained. We have designed and validated a panel of polymorphisms for individual sample identification consisting of 36 common polymorphisms that have been implicated in a wide range of diseases and an additional sex marker. This panel uniquely identifies our biorepository of approximately 20,000 samples and would continue to uniquely identify samples in biorepositories of over 100 million samples.

Methods

A panel of polymorphisms associated with at least one disease state in multiple populations was constructed using a cut-off of 0.20 or greater confirmed minor allele frequency in a European Caucasian population. The fingerprinting assay was tested using the MALDI-

SUBMITTER: Cross DS 

PROVIDER: S-EPMC2684120 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature