Post-challenge hyperglycemia in older adults is associated with increased cardiovascular risk profile.

ABSTRACT:

Context

Post-challenge hyperglycemia (PCH) is common in older adults and is associated with increased cardiovascular disease (CVD) risk and total mortality. However, PCH is rarely recognized in clinical settings, and the glycemic exposure and CVD risk profile of elderly individuals with PCH has not been defined.

Objective

The aim of the study was to characterize metabolic and CVD risk profile of elderly subjects with PCH and to determine the effect of acute postprandial metabolic changes on vascular biomarkers.

Design

We conducted a cross-sectional study with a standard meal challenge protocol.

Participants

Older adults with normal glucose tolerance (n = 30) or PCH (fasting glucose <126 mg/dl and 2-h glucose >or=170 mg/dl; n = 28) participated in the study.

SUBMITTER: Crandall JP 

PROVIDER: S-EPMC2684470 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature