Two-stage genome-wide association study identifies integrin beta 5 as having potential role in bull fertility.

ABSTRACT:

Background

Fertility is one of the most critical factors controlling biological and financial performance of animal production systems and genetic improvement of lines. The objective of this study was to identify molecular defects in the sperm that are responsible for uncompensable fertility in Holstein bulls. We performed a comprehensive genome wide analysis of single nucleotide polymorphisms (SNP) for bull fertility followed by a second-stage replication in additional bulls for a restricted set of markers.

Results

In the Phase I association study, we genotyped the genomic sperm DNA of 10 low-fertility and 10 high-fertility bulls using Bovine SNP Gene Chips containing approximately 10,000 random SNP markers. In these animals, 8,207 markers were found to be polymorphic, 97 o

SUBMITTER: Feugang JM 

PROVIDER: S-EPMC2684547 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature