High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.

ABSTRACT:

Background

Many different genetic alterations are observed in cancer cells. Individual cancer genes display point mutations such as base changes, insertions and deletions that initiate and promote cancer growth and spread. Somatic hypermutation is a powerful mechanism for generation of different mutations. It was shown previously that somatic hypermutability of proto-oncogenes can induce development of lymphomas.

Methodology/principal findings

We found an exceptionally high incidence of single-base mutations in the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) both located in 3p21.3 regions, LUCA and AP20 respectively. These regions contain clusters of tumor suppressor genes involved in multiple cancer types such as lung, kidney, breast, cervical, head and neck, nasophary

SUBMITTER: Kashuba VI 

PROVIDER: S-EPMC2684631 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature