Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer.

ABSTRACT:

Background

The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer.

Methodology/principal findings

A distinctive core of transcriptional regulators common to both fetal and adult primitive prostate cells was identified as well as molecules that are exclusive to each population. Elements common to fetal and adult prostate stem cells include expression profiles of Wnt, Shh and other pathways identified in stem cells of other organs, signatures of the aryl-hydrocarbon receptor, and up-regulation of components of the aldehyde dehydrogenase/retinoic acid receptor axis. There is also a significant lipid metabolism signature, m

SUBMITTER: Blum R 

PROVIDER: S-EPMC2684642 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature