Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?

ABSTRACT:

Introduction

Between 1993 and 2000 four acetylcholinesterase inhibitors were marketed as a symptomatic treatment for Alzheimer's disease (AD), as well as memantine in 2003. Current research is focused on finding drugs that favorably modify the course of the disease. However, their entrance into the market does not seem to be imminent.

Research development

The aim of AD research is to find substances that inhibit certain elements of the AD pathogenic chain (beta- and gamma-secretase inhibitors, alpha-secretase stimulants, beta-amyloid aggregability reducers or disaggregation and elimination inductors, as well as tau-hyperphosphorylation, glutamate excitotoxicity, oxidative stress and mitochondrial damage reducers, among other action mechanisms). Demonstrating a disease's reta

SUBMITTER: Robles A 

PROVIDER: S-EPMC2684708 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature