Gene classification based on amino acid motifs and residues: the DLX (distal-less) test case.

ABSTRACT:

Background

Comparative studies using hundreds of sequences can give a detailed picture of the evolution of a given gene family. Nevertheless, retrieving only the sequences of interest from public databases can be difficult, in particular, when working with highly divergent sequences. The difficulty increases substantially when one wants to include in the study sequences from many (or less well studied) species whose genomes are non-annotated or incompletely annotated.

Methodology/principal findings

In this work we evaluate the usefulness of different approaches of gene retrieval and classification, using the distal-less (DLX) gene family as a test case. Furthermore, we evaluate whether the use of a large number of gene sequences from a wide range of animal species, the use o

SUBMITTER: Fonseca NA 

PROVIDER: S-EPMC2685005 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature