Functional states of the genome-scale Escherichia coli transcriptional regulatory system.

ABSTRACT: A transcriptional regulatory network (TRN) constitutes the collection of regulatory rules that link environmental cues to the transcription state of a cell's genome. We recently proposed a matrix formalism that quantitatively represents a system of such rules (a transcriptional regulatory system [TRS]) and allows systemic characterization of TRS properties. The matrix formalism not only allows the computation of the transcription state of the genome but also the fundamental characterization of the input-output mapping that it represents. Furthermore, a key advantage of this "pseudo-stoichiometric" matrix formalism is its ability to easily integrate with existing stoichiometric matrix representations of signaling and metabolic networks. Here we demonstrate for the first time how this matrix

SUBMITTER: Gianchandani EP 

PROVIDER: S-EPMC2685017 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature