Ontology highlight
ABSTRACT:
SUBMITTER: Sylantyev S
PROVIDER: S-EPMC2685065 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Sylantyev Sergiy S Savtchenko Leonid P LP Niu Yin-Ping YP Ivanov Anton I AI Jensen Thomas P TP Kullmann Dimitri M DM Xiao Min-Yi MY Rusakov Dmitri A DA
Science (New York, N.Y.) 20080301 5871
The synaptic response waveform, which determines signal integration properties in the brain, depends on the spatiotemporal profile of neurotransmitter in the synaptic cleft. Here, we show that electrophoretic interactions between AMPA receptor-mediated excitatory currents and negatively charged glutamate molecules accelerate the clearance of glutamate from the synaptic cleft, speeding up synaptic responses. This phenomenon is reversed upon depolarization and diminished when intracleft electric f ...[more]