The genetic control of neocortex volume and covariation with neocortical gene expression in mice.

ABSTRACT:

Background

The size of the cerebral cortex varies widely within human populations, and a large portion of this variance is modulated by genetic factors. The discovery and characterization of these genes and their variants can contribute to an understanding of individual differences in brain development, behavior, and disease susceptibility. Here we use unbiased stereological techniques to map quantitative trait loci (QTLs) that modulate the volume of neocortex.

Results

We estimated volumes bilaterally in an expanded set of BXD recombinant inbred strains (n = 56 strains and 223 animals) taken from the Mouse Brain Library http://www.mbl.org. We generated matched microarray data for the cerebral cortex in the same large panel of strains and in parental neonates to efficiently n

SUBMITTER: Gaglani SM 

PROVIDER: S-EPMC2685397 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature