Genomic analysis reveals extensive gene duplication within the bovine TRB locus.

ABSTRACT:

Background

Diverse TR and IG repertoires are generated by V(D)J somatic recombination. Genomic studies have been pivotal in cataloguing the V, D, J and C genes present in the various TR/IG loci and describing how duplication events have expanded the number of these genes. Such studies have also provided insights into the evolution of these loci and the complex mechanisms that regulate TR/IG expression. In this study we analyze the sequence of the third bovine genome assembly to characterize the germline repertoire of bovine TRB genes and compare the organization, evolution and regulatory structure of the bovine TRB locus with that of humans and mice.

Results

The TRB locus in the third bovine genome assembly is distributed over 5 scaffolds, extending to approximately 730 Kb.

SUBMITTER: Connelley T 

PROVIDER: S-EPMC2685407 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature