Association of the timing of puberty with a chromosome 2 locus.

ABSTRACT:

Context

Twin studies indicate that the timing of pubertal onset is under strong genetic control. However, genes controlling pubertal timing in the general population have not yet been identified.

Objective

To facilitate the identification of genes influencing the timing of pubertal growth and maturation, we conducted linkage mapping of constitutional delay of growth and puberty (CDGP), an extreme variant of normal pubertal timing, in extended families.

Participants and methods

Fifty-two families multiply affected with CDGP were genotyped with 383 multiallelic markers. CDGP was defined based on growth charts (the age at onset of growth spurt, peak height velocity, or attaining adult height taking place at least 1.5 sd later than average). Chromosomal regions cosegregat

SUBMITTER: Wehkalampi K 

PROVIDER: S-EPMC2685475 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature