Evaluation of Wuchereria bancrofti GST as a vaccine candidate for lymphatic filariasis.

ABSTRACT:

Background

Lymphatic filarial parasites survive within the lymphatic vessels for years despite the complex immune environment surrounding them. Parasites possibly accomplish this by adopting various immunomodulatory strategies, which include release of glutathione-S-transferases (GSTs) that counteract the oxidative free radicals produced by the host. Since GSTs produced by parasites appear to be critical for the survival of parasites in the host, several studies evaluated the potential of parasite GSTs as vaccine candidates especially against schistosomiasis, fascioliasis and Seteria cervi. However, vaccine potential of GSTs of lymphatic filarial parasites has not been evaluated before.

Methods/principal findings

In the present study, the GST gene was cloned from the third s

SUBMITTER: Veerapathran A 

PROVIDER: S-EPMC2685978 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature